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生物大分子重点实验室

李梅博士研究员

中科院生物物理所，生物大分子国家重点实验室，研究组长

研究方向：光合作用相关（膜）蛋白及复合物的结构与功能

电子邮件：meili@ibp.ac.cn

电话：010-64888511

通讯地址：北京市朝阳区大屯路15号（100101）

英文版个人网页：http://english.ibp.cas.cn/sourcedb/rck/EN_xsszmL/202005/t20200519_341400.html

简历：

　　1991.09 - 1995.07 天津市南开大学，获理学学士学位

　　1999.09 - 2002.07 金沙集团1862cc科院生物物理研究所，获理学硕士学位

　　2004.09 - 2007.07 金沙集团1862cc科院生物物理研究所，获理学博士学位

　　1995.07 - 1999.06 中科院生物物理所，研究实习员

　　1999.07 - 2004.06 中科院生物物理所，助理研究员

　　2007.07 - 2016.12 中科院生物物理所，副研究员

　　2016.12 - 至今中科院生物物理所，研究员

获奖及荣誉：

社会任职：

研究方向：

　　光合作用是地球上最重要的化学反应之一，放氧光合生物利用太阳能，将二氧化碳转变为有机物，同时释放氧气，为地球上几乎全部生物提供物质能量来源。光合作用分为光反应和暗反应两个阶段。光反应是在光合生物的类囊体膜上进行的，由5个超大的膜蛋白复合物共同完成，光反应过程中产生的ATP和NADPH被后续的暗反应利用，最终生成碳水化合物。对光合作用机理及其调控机制的研究有望为解决当前面临的粮食、能源、环境等问题提供解决方案。

　　现阶段的研究内容主要集中在以下三个方面：

　　1. 光反应途径相关膜蛋白及复合物的结构与功能研究；

　　2. 光合生物对其捕光及电子传递的调节机理；

　　3. 光合作用暗反应中关键酶及其调控系统的结构与功能研究。

承担项目情况：

代表论著：

1. Zhang S¹, Zou B¹, Cao P, Su X, Xie F, Pan X, Li M*. Structural insights into photosynthetic cyclic electron transport. Mol Plant. 2023 Jan; 16(1): 187-205.

2. Wang J, Liu Z, Pan X, Wang N, Li L, Du Y, Li J*, Li M*. Structural and Biochemical Analysis Reveals Catalytic Mechanism of Fucoidan Lyase from Flavobacterium sp. SA-0082. Marine Drugs 2022 20(8): 533.

3. Yu G¹, Hao J¹, Pan X¹, Shi L, Zhang Y, Wang J, Fan H, Xiao Y, Yang F, Lou J, Chang W, Malnoe A*, Li M*. Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH. Nat Plants. 2022 July; 8:840-855.

4. Su X¹, Cao D¹, Pan X*, Shi L, Liu Z, Dall'Osto L, Bassi R, Zhang X*, Li M*. Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana. Mol Plant. 2022 Mar; 15(3):454-467. doi: 10.1016/j.molp.2022.01.020.

5. Cao P¹, Bracun L¹, Yamagata A¹, Christianson B, Negami T, Zou B, Terada T, Canniffe D, Shirouzu M*, Li M*, Liu LN*. Structural basis for the assembly and quinone transport mechanisms of the dimeric photosynthetic RC-LH1 supercomplex. Nat Commun. 2022 Apr; 13(1):1977. doi: 10.1038/s41467-022-29563-3.

6. Pan X¹, Tokutsu R¹, Li A¹, Takizawa K, Song C, Murata K, Yamasaki T, Liu Z*, Minagawa J* and Li M*. Structural basis of LhcbM5-mediated state transitions in green algae. Nat. Plants, 2021 Jul; 7:1119–1131.

7. Cao P, Pan X, Su X, Liu Z, Li M*. Assembly of eukaryotic photosystem II with diverse light-harvesting antennas. Curr Opin Struct Biol. 2020 Aug;63:49-57.

8. Yu A¹; Xie Y¹; Pan X; Zhang H; Cao P; Su X; Chang W; Li M*. Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle. Plant Cell. 2020 May;32(5):1556-1573.

9. Gao Y¹; Zhang H¹; Fan M; Jia C; Shi L; Pan X; Cao P; Zhao X; Chang W; Li M*. Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase. Nat Commun., 2020 Mar 23, 11:1525

10. Cao P¹; Cao D¹; Si L; Su X; Tian L; Chang W; Liu Z; Zhang X*; Li M*. Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex, Nature Plants. 2020 Feb 10, 6:167~176

11. Pan X¹; Cao D¹; Xie F¹; Xu F¹; Su X; Mi H; Zhang X*; Li M*. Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase. Nat Commun., 2020 Jan 30, 11(1):610

12. Pan X; Cao P; Su X; Liu Z; Li M*. Structural analysis and comparison of light-harvesting complexes I and II. BBA-Bioenergetics. 2020 Apr 1, 1861(4): 148038.

13. Su X¹, Ma J¹, Pan X¹, Zhao X, Chang W, Liu Z, Zhang X*, Li M*. Antenna arrangement and energy transfer pathways of a green algal photosystem I-LHCI supercomplex. Nat Plants. 2019 2019 Mar 8; 5: 273~281

14. Pan X¹, Ma J¹, Su X¹, Cao P, Chang W, Liu Z, Zhang X*, Li M*. Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II. Science. 2018, 360(6393):1109-1113.

15. Cao P, Su X, Pan X, Liu Z, Chang W, Li M*. Structure, assembly and energy transfer of plant photosystem II supercomplex. Biochim Biophys Acta Bioenerg. 2018, 1859(9):633-644.

16. Su X¹, Ma J¹, Wei X¹, Cao P¹, Zhu D, Chang W, Liu Z*, Zhang X*, Li M*. Structure and assembly mechanism of plant C(2)S(2)M(2)-type PSII-LHCII supercomplex. Science. 2017, 357(6353):815-820.

17. Wei X¹, Su X¹, Cao P, Liu X,Chang W, Li M*, Zhang X*, Liu Z*. Structure of spinach photosystem II-LHCII supercomplex at 3.2 Å resolution. Nature. 2016, 534(7605):69-74.

18. Fan M¹, Xiao Y¹, Li M*, Chang W*. Crystal Structures of Arabidopsis thaliana Oxalyl-CoA Synthetase Essential for Oxalate Degradation. Molecular Plant. 2016 9(9):1349-52

19. Fan M, Li M*, Liu Z, Cao P, Pan X, Zhang H, Zhao X, Zhang J, Chang W*. Crystal structures of the PsbS protein essential for photoprotection in plants. Nature Structural & Molecular Biology, 2015, 22(9):729-735.

20. Cao P¹, Xie Y¹, Li M*, Pan X, Zhang H, Zhao X, Su X, Cheng T,Chang W*. Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese-Induced Conformational Change. Molecular Plant, 2015,8, 664–666.

21. Jia C, Li M*, Li J, Zhang J, Zhang H, Cao P, Pan X, Lu X*, Chang W*. Structural insights into the catalytic mechanism of aldehyde-deformylating Oxygenases. Protein Cell, 2015, 6(1):55–67.

22. Zhang H, Li M*, Gao Y, Jia C, Pan X, Cao P, Zhao X, Zhang J, Chang W*. Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation. Protein Cell. 2015 Feb;6(2):147-51.

23. Wan T, Li M*, Zhao X, Zhang J, Liu Z, Chang W*. Crystal structure of a multilayer packed major light-harvesting complex: implications for grana stacking in higher plants. Molecular Plant. 2014 May;7(5):916-9.

（资料来源：李梅研究员，2023-06-29）