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中科院青促会会员

杨璐(已调离)  博士 项目副研究员  

金沙集团1862cc青年创新促进会会员 
中科院生物物理所,脑与认知科学国家重点实验室

研究方向:大脑皮层发育的细胞和分子基础

电子邮件:luyang@ibp.ac.cn

电       话:

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/sourcedb/rck/EN_zkyqchhy/202005/t20200519_339579.html

简       历:

  2007.09 - 2011.07  中国农业大学 生命科学理科实验班 理学学士

  2011.09 - 2017.07  北京大学生命科学学院 细胞生物学专业 博士学位

  2017.07 - 2019       金沙集团1862cc 项目副研究员

获奖及荣誉:

社会任职:

研究方向:

  oRG细胞由于在非人类灵长类动物与人脑皮层中的大量存在,被认为是大脑皮层由无脑回进化到有脑回的关键因素。我们主要运用单细胞转录组深度测序技术,筛选出人脑oRG细胞中的灵长类特异性标记基因,并综合基因条件性过表达技术进一步验证可以促进小鼠神经祖细胞的增殖,从而诱导产后小鼠的皮层增厚和沟回的形成。

承担项目情况:

代表论著:

1. Liu, J., W. Liu, L. Yang, Q. Wu, H. Zhang, A. Fang, L. Li, X. Xu, L. Sun, J. Zhang, F. Tang and X. Wang (2017). The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding. Cell Stem Cell.(Co First Author)

2. Dai, H. Q., B. A. Wang, L. Yang, J. J. Chen, G. C. Zhu, M. L. Sun, H. Ge, R. Wang, D. L. Chapman, F. Tang, X. Sun and G. L. Xu (2016). TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature 538(7626): 528-532.(Co Fisrt Author)

3. Yang, L., Z. C. Ma, C. Cao, Y. H. Zhang, X. L. Wu, R. Lee, B. Q. Hu, L. Wen, H. Ge, Y. Y. Huang, K. Q. Lao and F. C. Tang (2017). MR-seq: measuring a single cell's transcriptome repeatedly by RNA-seq. Science Bulleti 62(6): 391-398.(Co Fisrt Author) 

4. Wang, L., J. Zhang, J. Duan, X. Gao, W. Zhu, X. Lu, L. Yang, J. Zhang, G. Li, W. Ci, W. Li, Q. Zhou, N. Aluru, F. Tang, C. He, X. Huang and J. Liu (2014). Programming and inheritance of parental DNA methylomes in mammals. Cell 157(4): 979-991.

5. Streets, A. M., X. Zhang, C. Cao, Y. Pang, X. Wu, L. Xiong, L. Yang, Y. Fu, L. Zhao, F. Tang and Y. Huang (2014). Microfluidic single-cell whole-transcriptome sequencing. Proc Natl Acad Sci U S A 111(19): 7048-7053.

6. Yan, L., M. Yang, H. Guo, L. Yang, J. Wu, R. Li, P. Liu, Y. Lian, X. Zheng, J. Yan, J. Huang, M. Li, X. Wu, L. Wen, K. Lao, R. Li, J. Qiao and F. Tang (2013). Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol 20(9): 1131-1139.

7. Zhang, R. R., Q. Y. Cui, K. Murai, Y. C. Lim, Z. D. Smith, S. Jin, P. Ye, L. Rosa, Y. K. Lee, H. P. Wu, W. Liu, Z. M. Xu, L. Yang, Y. Q. Ding, F. Tang, A. Meissner, C. Ding, Y. Shi and G. L. Xu (2013). Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell 13(2): 237-245.

(资料来源:杨璐项目副研究员,2018-02-10)