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中科院青促会会员

李颖  博士 副研究员  

金沙集团1862cc青年创新促进会会员
中科院生物物理所,金沙集团1862cc感染与免疫重点实验室

研究方向:细胞生物学、肿瘤免疫

电子邮件:liy@ibp.ac.cn

电       话:010-64887560

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/sourcedb/rck/EN_zkyqchhy/202005/t20200519_339601.html

简       历:

  2002.09 - 2006.06  武汉大学生命科学学院,获理学学士学位

  2006.09 - 2011.06  武汉大学生命科学学院,获理学博士学位

  2012.03 - 2014.04  金沙集团1862cc,博士后

  2014.04 - 至今       金沙集团1862cc生物物里研究所,副研究员

获奖及荣誉:

  2015年 国家自然科学二等奖(第四完成人)

  2013年 “全国百篇优秀博士论文”获得者

  2013年 中国细胞生物学会-CST青年优秀论文二等奖

  2011、2006年 武汉大学优秀毕业生

社会任职:

研究方向:

  1. 记忆性T细胞分化的调控机制

  2. 树突状细胞分化的调控机制

  3. 抗肿瘤免疫和免疫治疗

承担项目情况:

代表论著:

1. Li Y, Cong Y, Jia M, He Q, Zhong H, Zhao Y, Li H, Yan M, You J, Liu J, Chen L, Hang H, Wang S. Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy. Nat Commun. 2021 Feb 11;12(1):951.

2. Lu N, Li Y, Zhang Z, Xing J, Sun Y, Yao S, Chen L. Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4. Nat Commun. 2018 Feb 21; 9(1):742.

3. Xu M, Liu M, Du X, Li S, Li H, Li X, Li Y, Wang Y, Qin Z, Fu YX, Wang S. Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype. J Immunol. 2015 May 15;194(10):4997-5006.

4. Li C, Wei J, Li Y, He X, Zhou Q, Yan J, Zhang J, Liu Y, Liu Y, Shu HB. Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. J Biol Chem. 2013 Jun 14;288(24):17908-17.

5. Chen H, Li Y, Zhang J, Ran Y, Wei J, Yang Y, Shu HB. RAVER1 is a coactivator of MDA5-mediated cellular antiviral response. J Mol Cell Biol. 2013 Apr; 5(2):111-9.

6. Li Y, Chen R, Zhou Q, Li C, Xu Z, Wang S, Mao AP, Zhang X, He W and Shu HB. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11770-5.

7. Wang X, Li Y, Mao A, Li C, Li Y, Tien P. Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex. Cell Mol Immunol. 2010 Sep; 7(5), 341-8.

8. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P and Shu HB. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. Proc Natl Acad Sci U S A. 2010 Jan 12; 107, 815-820.

9. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang FQ and Shu HB. ISG56 is a negative regulator of virus-triggered signaling and cellular antiviral response. Proc Natl Acad Sci U S A. 2009 Mar 20; 106, 7945-50.

10. Zhong B, Zhang L, Lei CQ, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity. 2009 Mar 20; 30, 397-407.

11. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB. The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity. 2008 Oct 17; 29, 538–550.

参编著作:

1.《抗病毒天然免疫》,舒红兵等,科学出版社,2009年(第七章)

发明专利:

1.王盛典,李颖,丛艳妮。一种靶向抗原特异性T细胞诱导其向干性记忆细胞分化的融合蛋白(专利申请号:201811069211.5)

(资料来源:李颖副研究员,2021-11-09)