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中科院青促会会员

李颖峰  博士 副研究员  

金沙集团1862cc青年创新促进会会员
中科院生物物理所,生物大分子国家重点实验室

研究方向:表观遗传学

电子邮件:liyingfeng@ibp.ac.cn

电       话:010-64888213

通讯地址:北京市朝阳区大屯路15号(100101)

英文版个人网页:http://english.ibp.cas.cn/sourcedb/rck/EN_zkyqchhy/202203/t20220322_339562.html

简       历:

  2006.09 – 2010.06  武汉大学生命科学学院,学士

  2010.09 – 2019.03  北京生命科学研究所/北京师范大学,博士

  2019.03 – 2021.11  中科院生物物理所,博士后

  2021.11 – 2022.01  中科院生物物理所,助理研究员

  2022.01 – 至今        中科院生物物理所,副研究员

获奖及荣誉:

社会任职:

研究方向:

  我们运用多学科前沿技术,致力于研究发育与疾病过程中的染色质调控机制:

  1. 哺乳动物早期胚胎染色质编程与重编程机制研究;

  2. 染色质调控蛋白突变的致病机制研究。

承担项目情况:

  1. 国家自然科学基金青年基金项目(32000559),2021-2023,负责人。

代表论著:

1. Zhang J#, Zhang Y#, You Q#, Huang C, Zhang T, Wang M, Zhang T, Yang X, Xiong J, Li Y, Liu C-P, Zhang Z, Xu R-M*, Zhu B*. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science. 2022, 375(6584): 1053-1058.

2. Ming X, Zhu B*, Li Y*. Mitotic inheritance of DNA methylation: more than just copy and paste. Journal of Genetics and Genomics. 2021, 48(1): 1-13.

3. Ming X#, Zhang Z#, Zou Z, Lv C, Dong Q, He Q, Yi Y, Li Y, Wang H, Zhu B*. Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration. Cell Res. 2020, 30(11): 980-996.

4. Du W, Dong Q, Zhang Z, Liu B, Zhou T, Xu R-m, Wang H, Zhu B, Li Y*. Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1. J Biol Chem. 2019, 294(22): 8907-8917.

5.Li Y#, Zhang Z#, Chen J#, Liu W, Lai W, Liu B, Li X, Liu L, Xu S, Dong Q, Wang M, Duan X, Tan J, Zheng Y, Zhang P, Fan G, Wong J, Xu G-L, Wang Z, Wang H, Gao S, Zhu B*. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. Nature. 2018, 564(7734): 136-140.

6. Li X, Shang E, Dong Q, Li Y, Zhang J, Xu S, Zhao Z, Shao W, Lv C, Zheng Y, Wang H, Lei X, Zhu B*, Zhang Z*. Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. J Biol Chem. 2018, 293(19): 7423-7436.

7. Huang C#, Zhang Z#, Xu M, Li Y, Li Z, Ma Y, Cai T, Zhu B*. H3.3-H4 Tetramer Splitting Events Feature Cell-Type Specific Enhancers. PLoS Genet. 2013, 9(6): e1003558.

8. Wu H, Chen X, Xiong J, Li Y, Li H, Ding X, Liu S, Chen S, Gao S, Zhu B*. Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Res. 2011, 21(2): 365-367.

(资料来源:李颖峰副研究员,2022-03-22)