报告题目：Epigenetic reprogramming and inheritance when life begins
报 告 人：颉伟 清华大学 教授
报告时间：2016年10月19日（星期三） 10:30
报告地点：中科院生物物理所图书馆二楼报告厅
主 持 人：俞洋 研究员
报告人简介：Dr. Wei Xie is a Principle Investigator at School of Life Sciences, Tsinghua University. His lab is interested in understanding epigenetic regulation of transcription in the mammalian genome that governs cellular development and related human diseases. They aim to decipher the mechanisms underlying a number of key biological processes: (1) epigenetics regulation of stem cell pluripotency and cell differentiation mediated by DNA methylation and chromatin modifications; (2) epigenetic regulation of early animal development; (3) the role of cis-regulatory elements such as enhancers and promoters in cell fate determination; (4) molecular mechanisms underlying human diseases linked to aberrant epigenetic regulation.
近期发表文章：
1.Bingjie Zhang, Hui Zheng, Bo Huang, Wenzhi Li, …, Jie Na,# Wei Xie# (2016). Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature 537 (553-557).
2.Hui Zheng, Bo Huang, Bingjie Zhang, …, Wei Xie# (2016). Resetting epigenetic memory by reprogramming of histone modifications in mammals. Molecular Cell 63 (1066-1079).
3.Jingyi Wu, Bo Huang, …, Wei Xie# (2016). The landscape of accessible chromatin in mammalian preimplantation embryos. Nature 534 (652-657).
4.Wei Xie, ..., Bing Ren# (2013) Epigenomic Analysis of Multi-lineage Differentiation of Human Embryonic Stem Cells. Cell 153: 1134-1148.
5.Wei Xie, …, Bing Ren# (2012) Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell 148: 816-831
