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深圳市第二人民医院联合实验室

聂国辉  主任医师教授 医学博士后 博士生导师  

深圳市第二人民医院(深圳大学第一附属医院)院长

研究方向:耳鼻咽喉科临床及基础研究

电子邮件:nieguohui@email.szu.edu.cn

电       话:0755-83366388

通讯地址:深圳市笋岗西路3002号

英文版个人网页:

简       历:

  教育背景:

  1980.09 - 1985.07  衡阳医学院, 临床医学系, 学士

  1988.09 - 1991.07  湖南医科大学,耳鼻咽喉科,硕士

  1992.09 - 1995.07  湖南医科大学,耳鼻咽喉科,博士

  工作经历:

  1985.07 - 1988.08  湖南省长沙市三医院,耳鼻喉科,医师

  1991.07 - 1995.09  湖南医科大学附属二院,主治医师

  1995.09 - 1997.09  同济医科大学协和医院,博士后,副主任医师,副教授

  1997.09 - 2011.06  深圳大学第一附属医院,副主任医师,主任医师,教授

  2011.06 - 2016.01  北京大学深圳医院,主任医师,教授

  2016.01 - 至今     深圳大学第一附属医院,主任医师,教授

获奖及荣誉:

社会任职:

 

研究方向:

  从事耳鼻咽喉科临床及基础研究35年余,有扎实的专业基础理论知识和熟练的临床手术技能,主要研究方向为听觉及平衡相关疾病的基础和临床,鼻咽癌早筛早诊断及治疗相关研究。先后承担国家、省市级课题20余项,获省级科研成果二等奖一项、三等奖二项;主编专业书籍1部,参编2部;至今在Cell MetabolismNature CommunicationsPNAS等期刊发表论文50余篇。

承担项目情况:

  1. 国家自然科学基金(面上项目),81970875,CRISPR-dCpf1 调控多基因联合表达拮抗前庭毛细胞损伤的实验研究,2020/01-2023/12, 59 万,在研,主持。

  2. 广东省自然科学基金(面上项目),2019A1515011495,基于CRISPR-dCpf1 技术保护前庭毛细胞损伤的基因表达调控机制研究,2019/10-2022/09,10 万,在研,主持。

  3. 深圳市科创委基础研究(学科布局),JCYJ20180508152528735,基20180166 常见高发恶性肿瘤的数据采集、挖掘及人工智能算法与装备研究,2019/01-2021/12,300万元,在研,主持。

  4. 深圳市科创委基础研究(学科布局),JCYJ20170413162242627,基于鼻咽癌精准分子分型诊疗体系的研究,2017/08-2020/08,200万元,在研,主持。

  5. 深圳市科创委,ZDSYS201707281114196,深圳市纳米酶肿瘤转化医学重点实验室,2018/04-2020/03,400万元,主持。

  6. 深圳市科创委国际合作研究项目,GJHZ20170313172439851,门控因子VEGFR3 参与 FGF-2 和 TNF-α诱导淋巴管生成在鼻咽癌转移中的机制研究,2017/07-2019/08,50 万元,在研,主持。

  7. 深圳市医疗卫生三名工程--金沙集团1862cc阎锡蕴院士纳米酶应用转化团队, SZSM201612031,2017/1-2021/12,1500万元,主持,在研。

  8. 深圳市发改委,s2016005470013,深圳眩晕诊治与前庭功能重塑公共服务平台项目,2017/01-2019/12,500万元,在研,主持。

  9. 福田区配套深圳市发改委,深圳眩晕诊治与前庭功能重塑公共服务平台项目,2018/01-2019/12,100万元,在研,主持。

代表论著:

  第一作者及通讯作者文章

  1. Zhenhong Wang, Bin Zhang, Bing Hu, Zhongjun Li, ChenYang Ma, Yu Chen, Yufeng Song, Han Zhang, Jun Liu,* and Guohui Nie, Two-dimensional tin diselenide nanosheets pretreated with an alkaloid for near- and mid-infrared ultrafast photonics, Research Article, 2327-9125/20/111687-10.

  2. Jianlin Zhang, Xuehui Chen, Juanji Hong, Aifa Tang, Yang Liu, Ni Xie*, Guohui Nie*, Xiyun Yan* and Minmin Liang*. Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses, SCIENCE CHINA

  3. Hanwei Wu, Yuchen Liu, Hongfang Duanc, Xiaoqin Fan, Yujie Wang, Jian Songa, Jinghong Han, Ming Yang, Lu Lu and Guohui Nie*,Identifification of differentially expressed circular RNAs in human nasopharygeal carcinoma,Galley Proof,20/08/2020; 13:41

  4. Hui Ding, Yanjuan Cai, Lizeng Gao, Minmin Liang, Beiping Miao, Hanwei Wu, Yang Liu, Ni Xie, Aifa Tang, Kelong Fan*, Xiyun Yan*, Guohui Nie*, "Exosome-like Nanozyme Vesicles for H2O2 ‐ Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma", Nano lett., 2019, 19: 203-209.

  5. Hui Ding#, Yajuan Cai, Jianxiogn Chen, Tong Lu, Weiping Wen*, Guohui Nie*, Xiaojun Wang*. "Cryodesiccation - driven crystallization preparation approach for zinc(II)-phthalocyanine nanodots in cancer photodynamic therapy and photoacoustic imaging", Microchim. Acta, 2019,186(4):237.

  6. Jian Song, Yujie Wang, Xiaoqin Fan, Hanwei Wu, Jinghong Han, Ming Yang, Lu Lu, Guohui Nie*, "Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway", Lipids Health Dis., 2019, 18: 46.

  7. Xiaoqin Fan#, Yuejie Wang#, Jian Song, Hanwei Wu, Ming Yang, Lu Lu, Xing Weng, Lusha Liu, Guohui Nie*. "MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma", Cancer Biol. Ther, 2019;20(10):1328-1336.

  8. Yujie Wang, Yuyang Wang, Xiaoqin Fan, Jian Song, Hanwei Wu, Jinghong Han, Lu Lu, Xin Weng, Guohui Nie*, "ABT-199-mediated inhibition of Bcl-2 as a potential therapeutic strategy for nasopharyngeal carcinoma", Biochem. Biophys. Res. Commun., 2018, 503(3), 1214-1220.

  9. Beiping Miao, Ruishi Zhang, Gui Yang, Jinjie Suna, Yuyan Tang, Weifeng Liang, Tao Liu, Zhong Wen, Pingchang Yangc, Guohui Nie*, Histone acetyltransferase 1 up regulates Bcl2L12 expression in nasopharyngeal cancer cells, Archives of Biochemistry and Biophysics, 646 (2018) 72-79.

  10. Fusen Wang, Guohui Nie*, Chengcheng Huang, Qian Li, Tiegang Li, Yuee Zou, Shaoyan Zhang, Xinyu Ceng,Investigation of cochlear hair cells and the perception of ultrasound signals in guinea pigs, Cell Mol Biol,2018 8 30;64(11):44-49.

  11. Hideki Iwamoto#, Mitsuhiko Abe#, Yunlong Yang#, Dongmei Cui, Takahiro Seki, Masaki Nakamura, Kayoko Hosaka, Sharon Lim, Jieyu Wu, Xingkang He, Xiaoting Sun, Yongtian Lu, Qingjun Zhou, Weiyun Shi, Takuji Torimura, Guohui Nie*, Qi Li*, Yihai Cao*, "Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance", Cell Metab., 2018, 28(1): 104-117.

  12. Yuchen Liu#*, Jinghong Han#, Zhicong Chen#, Hanwei Wu, Hongsong Dong, Guohui Nie, "Engineering cell signaling using tunable CRISPR-Cpf1-based transcription factors, Nat. Commun., 2017, 8(1): 2095-2095.

  13. Guohui Nie, Zhao Li, Honghong Duan, Liang Luo , Hongyi Hu, Xiaofan Chen and Wei Zhang,Long non coding RNA ZNF674 1 acts as a cancer suppressor in nasopharyngeal carcinoma, ONCOLOGY LETTERS,15: 10047-10054, 2018

  14. Caifeng Liu#, Yunjian Zhang#, Sharon Lim, Kayoko Hosaka, Yunlong Yang, Tatiana Pavlova, Twana Alkasalias, Johan Hartman, Lasse Jensen, Xiaoming Xing, Xinsheng Wang, Yongtian Lu, Guohui Nie*, Yihai Cao*, "A zebrafish model discovers a novel mechanism of stromal fibroblast-mediated cancer metastasis", Clin. Cancer Res., 2017, 23(16): 4769-4779.

  15. Yin Zhang#, Meili Sun#, Guichun Huang#, Linlin Yin, Qinghua Lai, Yunlong Yang, Xiaoming Xing, Guohua Yu, Yuping Sun*, Xinsheng Wang*, Guohui Nie*, Yizhi Liu*, Yihai Cao*, "Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy", Proc. Natl. Acad. Sci. USA, 2017, 114(26): E5226-E5235.

 

(资料来源:聂国辉教授,2020-12-07)