当前位置:  首页 >> 最新重要论文

最新重要论文

Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1, Nat Commun, 28 Feb 2023

发布时间:2023年02月28日

Nature Communications, 28 February, 2023, DOI:https://doi.org/10.1038/s41467-023-36838-w

Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1

Xiang Chen, Yan Wang, Zhonghe Xu, Meng-Li Cheng, Qing-Qing Ma, Rui-Ting Li, Zheng-Jian Wang, Hui Zhao, Xiaobing Zuo, Xiao-Feng Li, Xianyang Fang & Cheng-Feng Qin 

Abstract

Human RNA binding protein Musashi-1 (MSI1) plays a critical role in neural progenitor cells (NPCs) by binding to various host RNA transcripts. The canonical MSI1 binding site (MBS), A/GU(1-3)AG single-strand motif, is present in many RNA virus genomes, but only Zika virus (ZIKV) genome has been demonstrated to bind MSI1. Herein, we identified the AUAG motif and the AGAA tetraloop in the Xrn1-resistant RNA 2 (xrRNA2) as the canonical and non-canonical MBS, respectively, and both are crucial for ZIKV neurotropism. More importantly, the unique AGNN-type tetraloop is evolutionally conserved, and distinguishes ZIKV from other known viruses with putative MBSs. Integrated structural analysis showed that MSI1 binds to the AUAG motif and AGAA tetraloop of ZIKV in a bipartite fashion. Thus, our results not only identified an unusual viral RNA structure responsible for MSI recognition, but also revealed a role for the highly structured xrRNA in controlling viral neurotropism.

文章链接:https://www.nature.com/articles/s41467-023-36838-w

相关报道:/kyjz/zxdt/202303/t20230306_6688957.html

 

 

    附件下载: