当前位置:  首页 >> 最新重要论文

最新重要论文

A transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition, Dev Cell, 6 Feb 2024

发布时间:2024年02月06日

Developmental Cell, 6 February, 2024, DOI:https://doi.org/10.1016/j.devcel.2024.01.012

A transcription factor complex in Dictyostelium enables adaptive changes in macropinocytosis during the growth-to-development transition

Yazhou Hao, Yihong Yang, Hui Tu, Zhonglong Guo, Pengcheng Chen, Xiaoting Chao, Ye Yuan, Zhimeng Wang, Xilin Miao, Songlin Zou, Dong Li, Yanzhi Yang, Congying Wu, Bo Li, Lei Li, Huaqing Cai

Abstract

Macropinocytosis, an evolutionarily conserved endocytic pathway, mediates nonselective bulk uptake of extracellular fluid. It is the primary route for axenic Dictyostelium cells to obtain nutrients and has also emerged as a nutrient-scavenging pathway for mammalian cells. How cells adjust macropinocytic activity in various physiological or developmental contexts remains to be elucidated. We discovered that, in Dictyostelium cells, the transcription factors Hbx5 and MybG form a functional complex in the nucleus to maintain macropinocytic activity during the growth stage. In contrast, during starvation-induced multicellular development, the transcription factor complex undergoes nucleocytoplasmic shuttling in response to oscillatory cyclic adenosine 3′,5′-monophosphate (cAMP) signals, which leads to increased cytoplasmic retention of the complex and progressive downregulation of macropinocytosis. Therefore, by coupling macropinocytosis-related gene expression to the cAMP oscillation system, which facilitates long-range cell-cell communication, the dynamic translocation of the Hbx5-MybG complex orchestrates a population-level adjustment of macropinocytic activity to adapt to changing environmental conditions.

文章链接:https://www.sciencedirect.com/science/article/pii/S1534580724000339?via%3Dihub

相关报道:https:/kyjz/zxdt/202402/t20240205_6986000.html


    附件下载: